High tryptophan diet reduces CA1 intraneuronal ss-amyloid in the triple transgenic mouse model of Alzheimer's disease.

0384005 - ÚEM 2013 RIV US eng J - Journal Article
Noristani, H. N. - Verkhratsky, A. - Rodríguez Arellano, Jose Julio
High tryptophan diet reduces CA1 intraneuronal ss-amyloid in the triple transgenic mouse model of Alzheimer's disease.
Aging Cell. Roč. 11, č. 5 (2012), s. 810-822. ISSN 1474-9718. E-ISSN 1474-9726
R&D Projects: GA ČR GA309/09/1696; GA ČR GA305/08/1384; GA ČR(CZ) GAP304/11/0184
Institutional research plan: CEZ:AV0Z50390703
Institutional support: RVO:68378041
Keywords : Alzheimer's disease * hippocampus * L-tryptophan diet
Subject RIV: FH - Neurology
Impact factor: 5.705, year: 2012

Alzheimer's disease (AD) is a progressive neurodegenerative disease that impairs mnesic functions. The histopathology of the disease is manifested by the accumulation of intracellular β-amyloid (Aβ) and subsequent formation of neuritic plaques as well as the presence neurofibrillary tangles in specific brain regions associated with learning and memory including the hippocampus. Our results show that increased dietary TrP intake reduces intraneuronal Aβ load in the 3xTg-AD mouse model of AD, suggesting that enhanced TrP intake and in consequence a potential increase in 5-HT neurotransmission may be effective in reducing plaque pathology in AD.
Permanent Link: http://hdl.handle.net/11104/0215099