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Characterization of solid polymer dispersions of active pharmaceutical ingredients by 19F MAS NMR and factor analysis

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    0383512 - ÚMCH 2013 RIV NL eng J - Journal Article
    Urbanová, Martina - Brus, Jiří - Šeděnková, Ivana - Policianová, Olivia - Kobera, Libor
    Characterization of solid polymer dispersions of active pharmaceutical ingredients by 19F MAS NMR and factor analysis.
    Spectrochimica Acta Part A-Molecular and Biomolecular Spectroscopy. Roč. 100, 1 January (2013), s. 59-66. ISSN 1386-1425. E-ISSN 1873-3557
    R&D Projects: GA ČR GPP106/11/P426; GA MŠMT 2B08021
    Institutional research plan: CEZ:AV0Z40500505
    Institutional support: RVO:61389013
    Keywords : solid-state NMR * factor analysis * 19F MAS NMR
    Subject RIV: FR - Pharmacology ; Medidal Chemistry
    Impact factor: 2.129, year: 2013

    In this contribution the ability of 19F MAS NMR spectroscopy to probe structural variability of poorly water-soluble drugs formulated as solid dispersions in polymer matrices is discussed. The application potentiality of the proposed approach is demonstrated on a moderately sized active pharmaceutical ingredient (API, Atorvastatin) exhibiting extensive polymorphism. In this respect, a range of model systems with the API incorporated in the matrix of polvinylpyrrolidone (PVP) was prepared.
    Permanent Link: http://hdl.handle.net/11104/0216060

     
     
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