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Signal transduction pathways participating in homeostasis and malignant transformation of the intestinal tissue
- 1.0383116 - ÚMG 2013 RIV SK eng J - Journal Article
Krausová, Michaela - Kořínek, Vladimír
Signal transduction pathways participating in homeostasis and malignant transformation of the intestinal tissue.
Neoplasma. Roč. 59, č. 6 (2012), s. 708-718. ISSN 0028-2685. E-ISSN 1338-4317
R&D Projects: GA ČR GAP305/11/1780; GA ČR GAP305/12/2347; GA ČR GAP304/11/1252; GA ČR GD204/09/H058
Keywords : colorectal cancer * epithelium * gut * intestine * mouse models * stem cells
Subject RIV: EB - Genetics ; Molecular Biology
Impact factor: 1.574, year: 2012
Intestinal homeostasis is a complex and tightly regulated process governed by a variety of signalling pathways that balance cell proliferation and differentiation. As revealed by extensive use of defined mouse models, perturbations within the signalling circuitry trigger initial expansion of premalignant cells. In this review, we attempt to summarise recent advances in the knowledge of the cellular signalling mechanisms that drive tumorigenesis in the human and mouse intestine.
Permanent Link: http://hdl.handle.net/11104/0216396
Number of the records: 1