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Minimally invasive drug delivery to the cochlea through application of nanoparticles to the round window membrane
- 1.0383074 - ÚEM 2013 RIV GB eng J - Journal Article
Buckiová, Daniela - Ranjan, S. - Newman, T. A. - Johnston, A. H. - Sood, R. - Kinnunen, P. K. J. - Popelář, Jiří - Chumak, Tetyana - Syka, Josef
Minimally invasive drug delivery to the cochlea through application of nanoparticles to the round window membrane.
Nanomedicine. Roč. 7, č. 9 (2012), s. 1339-1354. ISSN 1743-5889. E-ISSN 1748-6963
R&D Projects: GA ČR GA309/07/1336; GA MŠMT(CZ) LC554
Institutional research plan: CEZ:AV0Z50390512
Keywords : nanoparticles * cochlea * drug delivery
Subject RIV: FH - Neurology
Impact factor: 5.260, year: 2012
Liposome and polymersome nanoparticles were tested as potential tools for drug delivery to the cochlea via application onto the round window membrane in adult mice. The results demonstrated that liposome and polymersome nanoparticles are capable of carrying a payload into the inner ear that elicits a biological effect, with consequences measurable by a functional readout.
Permanent Link: http://hdl.handle.net/11104/0007210
Number of the records: 1