Deregulation of Gene Expression Induced by Environmental Tobacco Smoke Exposure in Pregnancy

0382957 - ÚEM 2013 RIV GB eng J - Journal Article
Votavová, H. - Dostálová-Merkerová, M. - Krejčík, Z. - Fejglová, K. - Vašíková, A. - Pastorková, Anna - Tabashidze, Nana - Topinka, Jan - Balascak, I. - Šrám, Radim - Brdička, R.
Deregulation of Gene Expression Induced by Environmental Tobacco Smoke Exposure in Pregnancy.
Nicotine & Tobacco Research. Roč. 14, č. 9 (2012), s. 1073-1082. ISSN 1462-2203. E-ISSN 1469-994X
R&D Projects: GA MŠMT 2B06088
Institutional research plan: CEZ:AV0Z50390703
Keywords : environmental tobacco smoke * cord blood * microarray
Subject RIV: DN - Health Impact of the Environment Quality
Impact factor: 2.477, year: 2012

To extend the knowledge on the molecular effects of environmental tobacco smoke exposure (ETS) in pregnancy, transcriptome alterations in passive smokers (PS, pregnant women) were analyzed. Using Illumina Expression Beadchips with 24,526 transcript probes, gene expression patterns were assayed in placentas from passive smokers (N=25) and non-exposed counterparts (N=35), and in cord blood cells from their babies. ETS exposure was evaluated by questionnaire disclosure and cotinine measurement in maternal and cord blood. The results demonstrate that even low dose exposure to ETS during pregnancy leads to significant deregulation of transcription in placental and fetal cells. The effect of ETS on the fetus is primarily indirect, mediated via deregulation of placental functions.
Permanent Link: http://hdl.handle.net/11104/0007208