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Dynamics of caspase-3 activation and inhibition in embryonic micromasses evaluated by a photon-counting chemiluminiscence approach

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    0381779 - ÚIACH 2013 RIV US eng J - Journal Article
    Chlastáková, Ivana - Lišková, Marcela - Kudělová, Judita - Dubská, L. - Klepárník, Karel - Matalová, Eva
    Dynamics of caspase-3 activation and inhibition in embryonic micromasses evaluated by a photon-counting chemiluminiscence approach.
    In Vitro - Cellular and Developmental Biology. Animal Section. Roč. 48, č. 9 (2012), s. 545-549. ISSN 1071-2690. E-ISSN 1543-706X
    R&D Projects: GA ČR(CZ) GAP206/11/2377; GA MŠMT(CZ) EE2.3.20.0182
    Grant - others:GA ČR(CZ) GAP502/12/1285
    Program: GA
    Institutional research plan: CEZ:AV0Z50450515; CEZ:AV0Z40310501
    Keywords : Caspases * apoptpsis * chemiluminiscence * camptothecin
    Subject RIV: CB - Analytical Chemistry, Separation; ED - Physiology (UZFG-Y)
    Impact factor: 1.289, year: 2012

    Caspases are key enzymatic components of the intracellular apoptotic machinery and their role in mammalian systems is often studied using fluoromethylketone (FMK) inhibitors. This work therefore focuses on an exact evaluation of caspase-3 FMK inhibition dynamics in camptothecin induced mesenchymal micromasses. A photon-counting chemiluminiscence approach was applied for quantification of active caspase-3.
    Permanent Link: http://hdl.handle.net/11104/0212171

     
     
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