Bacteria and their Toxins Tamed for Immunotherapy

0381770 - MBÚ 2013 RIV NL eng J - Journal Article
Adkins, Irena - Holubová, Jana - Kosová, Martina - Sadílková, Lenka
Bacteria and their Toxins Tamed for Immunotherapy.
Current Pharmaceutical Biotechnology. Roč. 13, č. 8 (2012), s. 1446-1473. ISSN 1389-2010. E-ISSN 1873-4316
R&D Projects: GA ČR GP310/09/P582; GA ČR GA310/08/0447
Institutional support: RVO:61388971
Keywords : Adjuvant * antigen delivery * antigen presentation
Subject RIV: CE - Biochemistry
Impact factor: 2.690, year: 2012

Bacterial toxins share the ability to enter host cells to target various intracellular proteins and to modulate host immune responses. Over the last 20 years, toxins and their mutated variants, as well as live attenuated bacteria, have been exploited for vaccination and immunotherapy of various infectious, malignant and autoimmune diseases. The ability of Bordetella pertussis adenylate cyclase toxin to translocate its adenylate cyclase domain across the host cell membrane, as well as the pathways of intracellular trafficking of Bacillus anthracis lethal and edema toxins, Shigella dysenteriae shiga toxin or Escherichia coli shiga-like toxin, have been repeatedly exploited for the delivery of antigenic epitopes into host cells and for stimulation of antigen-specific T cell responses
Permanent Link: http://hdl.handle.net/11104/0212162