Semen and serum inhibin B, and sperm quality in infertile men

0380618 - BTÚ 2013 BG eng J - Journal Article
Babčová, K. - Ulčová-Gallová, Z. - Bibková, K. - Mičanová, Z. - Pěknicová, Jana
Semen and serum inhibin B, and sperm quality in infertile men.
Andrologiia. Roč. 21, č. 2 (2012), s. 3-12. ISSN 1310-3806
Institutional research plan: CEZ:AV0Z50520701
Keywords : inhibin B * intra-acrosomal proteins * sperm agglutinating antibodies * male infertility
Subject RIV: EC - Immunology

Inhibin B as an heterodimeric protein, participating in the negative biological feedback to the FSH. Levels of inhibin B in serum and seminal plasma were studied by ELISA method (pathologic levels ≤ 400 pg/ml in serum and ≤ 600 pg/ml in seminal plasma). The acrosome state was evaluated by monoclonal antibodies Hs-8 and HS-14. Indirect immunofluorescence test was used (normal state 75% positive cells by HS-8, 86% by HS-14). Direct MAR test for sperm-agglutinating antibodies were used. Low levels of inhibin B together with the pathology of acrosome, and/or sperm-agglutinating antibodies are very important risk factor in pathogenesis of human sperm.
Permanent Link: http://hdl.handle.net/11104/0211277