Age-dependent salt hypertension in Dahl rats: fifty years of research

0380467 - FGÚ 2013 RIV CZ eng J - Journal Article
Zicha, Josef - Dobešová, Zdenka - Vokurková, Martina - Rauchová, Hana - Hojná, Silvie - Kadlecová, Michaela - Behuliak, Michal - Vaněčková, Ivana - Kuneš, Jaroslav
Age-dependent salt hypertension in Dahl rats: fifty years of research.
Physiological Research. Roč. 61, Suppl.1 (2012), S35-S87. ISSN 0862-8408. E-ISSN 1802-9973
R&D Projects: GA MŠMT(CZ) 1M0510; GA ČR(CZ) GA305/09/0336; GA ČR(CZ) GAP304/12/0259
Institutional research plan: CEZ:AV0Z50110509
Institutional support: RVO:67985823
Keywords : blood pressure * cell membrane transport * hemodynamics * vasoactive systems * cell calcium handling
Subject RIV: FA - Cardiovascular Diseases incl. Cardiotharic Surgery
Impact factor: 1.531, year: 2012

We also searched for the age-dependent impact of environmental and pharmacological interventions, which modify the development of high blood pressure and/or organ damage, if they influence the salt-sensitive organism in particular critical periods of development (developmental windows). Thus, severe self-sustaining salt hypertension in young Dahl rats is characterized by pronounced dysbalance between augmented sympathetic hyperactivity and relative nitric oxide deficiency, attenuated baroreflex as well as by a major increase of residual blood pressure indicating profound remodeling of resistance vessels. Salt hypertension development in young but not in adult Dahl rats can be attenuated by preventive increase of potassium or calcium intake. On the contrary, moderate salt hypertension in adult Dahl rats is attenuated by superoxide scavenging or endothelin-A receptor blockade which do not affect salt hypertension development in young animals
Permanent Link: http://hdl.handle.net/11104/0211172