0379733 - ÚEM 2013 RIV DE eng J - Journal Article
Halásová, E. - Mataková, T. - Mušák, L. - Poláková, Veronika - Letková, L. - Dobrota, D. - Vodička, Pavel
Evaluating chromosomal damage in workers exposed to hexavalent chromium and the modulating role of polymorphisms of DNA repair genes.
International Archives of Occupational and Environmental Health. Roč. 85, č. 5 (2012), s. 473-481. ISSN 0340-0131. E-ISSN 1432-1246
Grant - others:MŠ SR(SK) 2007-UK48/13; MŠ SR(SK) 1/0537/10
Institutional research plan: CEZ:AV0Z50390703
Keywords : XPD Lys751Gln * XPG Asn114His * XPC Lys939Gln
Subject RIV: EB - Genetics ; Molecular Biology
Impact factor: 2.097, year: 2012

Hexavalent chromium causes damage of DNA. We investigated 73 occupationally exposed workers and 71 control individuals for chromosomal aberrations as well as for tentative modulating role of polymorphisms in DNA repair genes on chromosomal damage with respect to the blood concentration of chromium. No apparent increase in chromosomal damage was recorded in chromium-exposed welders in comparison with controls, but genetic make-up in DNA repair genes may increase susceptibility toward averse efect of chromium.
Permanent Link: http://hdl.handle.net/11104/0210618