Toxicity study of antimicrobial peptides from wild bee venom and their analogs toward mammalian normal and cancer cells

0379323 - ÚOCHB 2013 RIV US eng J - Journal Article
Slaninová, Jiřina - Mlsová, V. - Kroupová, H. - Alán, Lukáš - Tůmová, Tereza - Monincová, Lenka - Borovičková, Lenka - Fučík, Vladimír - Čeřovský, Václav
Toxicity study of antimicrobial peptides from wild bee venom and their analogs toward mammalian normal and cancer cells.
Peptides. Roč. 33, č. 1 (2012), s. 18-26. ISSN 0196-9781. E-ISSN 1873-5169
R&D Projects: GA ČR GA203/08/0536
Institutional research plan: CEZ:AV0Z40550506; CEZ:AV0Z50110509
Keywords : antimicrobial peptides * venom * hymenoptera * cancer cells * toxicity * confocal microscopy
Subject RIV: CE - Biochemistry
Impact factor: 2.522, year: 2012

Cytotoxicity of AMPs from wild bees and some of their analogs was tested toward two normal cell lines and three cancer cell lines. The cancer cells HeLa S3 and CEM were very sensitives to the peptides, for the other cell lines to be killed, the concentrations had to be four to twenty times higher.
Permanent Link: http://hdl.handle.net/11104/0210565