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Cell Differentiation within a Yeast Colony: Metabolic and Regulatory Parallels with a Tumor-Affected Organism
- 1.0379058 - MBÚ 2013 RIV US eng J - Journal Article
Čáp, M. - Štěpánek, L. - Harant, Karel - Váchová, Libuše - Palková, Z.
Cell Differentiation within a Yeast Colony: Metabolic and Regulatory Parallels with a Tumor-Affected Organism.
Molecular Cell. Roč. 46, č. 4 (2012), s. 436-448. ISSN 1097-2765. E-ISSN 1097-4164
R&D Projects: GA ČR GA204/08/0718; GA MŠMT(CZ) LC531
Institutional support: RVO:61388971
Keywords : LONG-TERM SURVIVAL * SACCHAROMYCES-CEREVISIAE * GENE-EXPRESSION
Subject RIV: CE - Biochemistry
Impact factor: 15.280, year: 2012
Nutrient sensing and metabolic reprogramming are crucial for metazoan cell aging and tumor growth. Here, we identify metabolic and regulatory parallels between a layered, multicellular yeast colony and a tumor-affected organism. During development, a yeast colony stratifies into U and L cells occupying the upper and lower colony regions, respectively. U cells activate a unique metabolism controlled by the glutamine-induced TOR pathway, amino acid-sensing systems (SPS and Gcn4p) and signaling from mitochondria with lowered respiration
Permanent Link: http://hdl.handle.net/11104/0210336
Number of the records: 1