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Tumor selective targeting and light induced cytotoxicity of Zn-protoporphyrin conjugated hydroxypropylmethacrylamide polymer (HPMA-ZnPP) micelle
- 1.0379002 - ÚMCH 2013 US eng C - Conference Paper (international conference)
Nakamura, H. - Haibo, Q. - Long, L. - Šubr, Vladimír - Hitaka, Y. - Jun, F. - Ulbrich, Karel - Maeda, H.
Tumor selective targeting and light induced cytotoxicity of Zn-protoporphyrin conjugated hydroxypropylmethacrylamide polymer (HPMA-ZnPP) micelle.
CRS 2012 Program. St. Paul: The Controlled Release Society, 2012, 424_1-424_2.
[Annual Meeting & Exposition of the Controlled Release Society /39./ - CRS 2012. Québec (CA), 15.07.2012-18.07.2012]
Grant - others:AV ČR(CZ) AP0802
Program: Akademická prémie - Praemium Academiae
Institutional research plan: CEZ:AV0Z40500505
Institutional support: RVO:61389013
Keywords : polymer micelles * protoporphyrin * poly[N-(2-hydroxypropyl)methacrylamide] conjugates
Subject RIV: CD - Macromolecular Chemistry
HPMA-ZnPP forms micelle structure in aqueous solution, which has ability to generate singlet oxygen upon light irradiation. In in vivo setting, HPMA-ZnPP accumulates in the tumor selectively by EPR effect, and its specific accumulation at the tumor tissue was demonstrated by fluorescent imaging. Furthermore HPMA-ZnPP exhibits remarkable anti-tumor activity by light irradiation.
Permanent Link: http://hdl.handle.net/11104/0210292
Number of the records: 1