Overexpression of calreticulin in malignant and benign breast tumors: relationship with humoral immunity

0378925 - MBÚ 2013 RIV CH eng J - Journal Article
Eric-Nikolic, A. - Milanovic, Z. - Sánchez, Daniel - Pekáriková, Aneta - Džodic, R. - Matic, I. Z. - Tučková, Ludmila - Jevric, M. - Buta, M. - Raškovic, S. - Juranic, Z.
Overexpression of calreticulin in malignant and benign breast tumors: relationship with humoral immunity.
Oncology. Roč. 82, č. 1 (2012), s. 48-55. ISSN 0030-2414. E-ISSN 1423-0232
R&D Projects: GA AV ČR IAA500200709; GA MŠMT 2B06155; GA ČR GD310/08/H077
Institutional research plan: CEZ:AV0Z50200510
Keywords : Breast tumor * Calreticulin * ELISA anti-calreticulin antibodies
Subject RIV: EC - Immunology
Impact factor: 2.165, year: 2012

Calreticulin is a multicompartmental protein which regulates many important cellular responses. The aim of this study was to elucidate whether the intensity and location of calreticulin overexpression in tumor cells are related to the elevated humoral immunity to calreticulin in patients with benign or malignant breast disease. Methods: This study involved 27 patients with benign and 58 patients with malignant breast tumors before surgical resection and 38 healthy volunteers. Cytoplasmatic or membranous calreticulin overexpression in malignant or benign cells in paraffin-embedded tissues was determined using immunohistochemistry
Permanent Link: http://hdl.handle.net/11104/0210237