The bZIP Transcription Factor Rca1p Is a Central Regulator of a Novel CO2 Sensing Pathway in Yeast

0378773 - MBÚ 2013 RIV US eng J - Journal Article
Cottier, F. - Raymond, M. - Kurzai, O. - Bolstad, M. - Leewattanapasuk, W. - Jiménez-López, M. - Lorenz, M. C. - Sanglard, D. - Váchová, Libuše - Pavelka, N. - Palková, Z. - Mühlschlegel, F. A.
The bZIP Transcription Factor Rca1p Is a Central Regulator of a Novel CO2 Sensing Pathway in Yeast.
PLoS Pathogens. Roč. 8, č. 1 (2012), e1002485. ISSN 1553-7366. E-ISSN 1553-7374
R&D Projects: GA MŠMT(CZ) LC531
Institutional research plan: CEZ:AV0Z50200510
Keywords : CARBONIC-ANHYDRASE CAN2 * CANDIDA-ALBICANS * SACCHAROMYCES-CEREVISIAE
Subject RIV: EE - Microbiology, Virology
Impact factor: 8.136, year: 2012

Like many organisms the fungal pathogen Candida albicans senses changes in the environmental CO2 concentration. This response involves two major proteins: adenylyl cyclase and carbonic anhydrase (CA). Here, we demonstrate that CA expression is tightly controlled by the availability of CO2 and identify the bZIP transcription factor Rca1p as the first CO2 regulator of CA expression in yeast. We show that Rca1p upregulates CA expression during contact with mammalian phagocytes and demonstrate that serine 124 is critical for Rca1p signaling, which occurs independently of adenylyl cyclase
Permanent Link: http://hdl.handle.net/11104/0210161