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Evaluation of combined methotrexate therapy with antioxidant active substances in adjuvant-induced arthritis. A new approach to rheumatoid arthritis treatment
- 1.0378674 - ÚOCHB 2013 SK eng C - Conference Paper (international conference)
Dráfi, F. - Bauerová, K. - Kuncírová, V. - Poništ, S. - Mihalová, D. - Boldyrev, A. - Harmatha, Juraj - Nosáľ, R.
Evaluation of combined methotrexate therapy with antioxidant active substances in adjuvant-induced arthritis. A new approach to rheumatoid arthritis treatment.
Drugs their Action in Pharmacology and Toxicology. Bratislava: Institute of Experimental Pharmacology & Toxicology SAS, 2012 - (Bauer, V.; Mach, M.; Navarová, J.; Sotníková, R.), s. 161-175. ISBN 978-80-971042-0-7.
[Drugs: Their Action in Pharmacology and Toxicology. Bratislava (SK), 31.05.2012]
Institutional research plan: CEZ:AV0Z40550506
Keywords : arthritis * oxidative stress * pinosylvin
Subject RIV: CC - Organic Chemistry
The aim was to examine the effect of pinosylvin and carnisine in monotherapy, and the combined effect of carnisine and methotrexate on disease progression in arthritic rats. The monitored parameters were: change of hind paw volume, arthritic score in arthrogram , enzyme activity and induced oxidation of lipids. Results indicated reduction of oxidative stress in adjuvant arthritis.
Permanent Link: http://hdl.handle.net/11104/0210087
Number of the records: 1