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Synthesis of Novel N-Branched Acyclic Nucleoside Phosphonates As Potent and Selective Inhibitors of Human, Plasmodium falciparum and Plasmodium vivax 6-Oxopurine Phosphoribosyltransferases
- 1.0378633 - ÚOCHB 2013 RIV US eng J - Journal Article
Hocková, Dana - Keough, D. T. - Janeba, Zlatko - Wang, T. - de Jersey, J. - Guddat, L. W.
Synthesis of Novel N-Branched Acyclic Nucleoside Phosphonates As Potent and Selective Inhibitors of Human, Plasmodium falciparum and Plasmodium vivax 6-Oxopurine Phosphoribosyltransferases.
Journal of Medicinal Chemistry. Roč. 55, č. 13 (2012), s. 6209-6223. ISSN 0022-2623. E-ISSN 1520-4804
R&D Projects: GA ČR GAP207/11/0108; GA MŠMT 1M0508
Grant - others:NHMRC(AU) 569703; NHMRC(AU) 1030353
Institutional support: RVO:61388963
Keywords : enzyme inhibitors * aza-ANPs * malaria
Subject RIV: CC - Organic Chemistry
Impact factor: 5.614, year: 2012
Series of novel acyclic nucleoside phosphonates - aza-ANPs - was designed as potent and selective inhibitors of 6-oxopurine phosphoribosyltransferases, crucial enzyme for the survival of malarial parasites.
Permanent Link: http://hdl.handle.net/11104/0210055
Number of the records: 1