Chiral capillary electrophoresis in the investigation of racemization pathway of novel helical dications – helquats

0378599 - ÚOCHB 2013 CZ eng A - Abstract
Adriaenssens, Louis - Severa, Lukáš - Koval, Dušan - Císařová, I. - Martínez, B. M. - Escudero-Adán, E. C. - Novotná, P. - Sázelová, Petra - Vávra, Jan - Pohl, Radek - Šaman, David - Urbanová, M. - Kašička, Václav - Teplý, Filip
Chiral capillary electrophoresis in the investigation of racemization pathway of novel helical dications – helquats.
Acta Universitatis Palackianae Olomucensis. Facultas Rerum Naturalium. Chemica 50S. Olomouc: Faculty of Science, Palacký University Olomouc, 2012 - (Maier, V.; Ševčík, J.). s. 110-110. ISBN 978-80-244-3115-4. ISSN 0232-0061.
[International Symposium Advances in Chromatography and Electrophoresis and Chiranal. 11.06.2012-14.06.2012, Olomouc]
R&D Projects: GA ČR GAP207/10/2391; GA ČR(CZ) GA203/08/1428
Grant - others:GA ČR(CZ) GAP206/12/0453
Program: GA
Institutional support: RVO:61388963
Keywords : racemization * helquats * chiral capillary electrophoresis
Subject RIV: CB - Analytical Chemistry, Separation

Chiral capillary electrophoresis with highly sulphated cyclodextrins-based stereoselectors has been applied to monitor racemization pathway of novel helical dications – helquats, including isolation of the stable saddle-shaped intermediate. In conjunction with spectral methods (NMR, X-ray crystallography, CD) and ab-initio calculations, individual species were characterized in detail and a mechanism of the stereocontrolled interconversion process was documented.
Permanent Link: http://hdl.handle.net/11104/0210031