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Immunochemical detection of oxidatively damaged DNA
- 1.0377754 - ÚEM 2013 RIV GB eng J - Journal Article
Rössner ml., Pavel - Šrám, Radim
Immunochemical detection of oxidatively damaged DNA.
Free Radical Research. Roč. 46, č. 4 (2012), s. 492-522. ISSN 1071-5762. E-ISSN 1029-2470
R&D Projects: GA MŽP(CZ) SP/1B3/50/07; GA MŠMT 2B08005; GA ČR GAP503/11/0084
Institutional research plan: CEZ:AV0Z50390703
Institutional support: RVO:68378041
Keywords : oxidative DNA damage * ELISA * immunohistochemistry
Subject RIV: DN - Health Impact of the Environment Quality
Impact factor: 3.279, year: 2012
Several methods have been developed to detect oxidatively damaged DNA. This review evaluates the studies dealing with the detection of 8-oxodG in humans, the most abundant oxidized nucleoside. Authors concentrated especially on studies which used enzyme linked immunosorbent assay and immunohistochemistry to detect 8-oxodG in humans, laboratory animals and in cell lines. Oxidative damage observed in these organisms resulted from disease, exposure to environmental pollutants of from in vitro treatment with various chemical and physical factors.
Permanent Link: http://hdl.handle.net/11104/0209834
Number of the records: 1