An efficient microwave-assisted synthesis and biological properties of polysubstituted pyrimidinyl- and 1,3,5-triazinylphosphonic acids

0377689 - ÚOCHB 2013 RIV GB eng J - Journal Article
Jansa, Petr - Hradil, Ondřej - Baszczyňski, Ondřej - Dračínský, Martin - Klepetářová, Blanka - Holý, Antonín - Balzarini, J. - Janeba, Zlatko
An efficient microwave-assisted synthesis and biological properties of polysubstituted pyrimidinyl- and 1,3,5-triazinylphosphonic acids.
Tetrahedron. Roč. 68, č. 3 (2012), s. 865-871. ISSN 0040-4020. E-ISSN 1464-5416
R&D Projects: GA AV ČR KJB400550903; GA MŠMT 1M0508
Grant - others:K.U. Leuven(BE) GOA 10/014
Institutional research plan: CEZ:AV0Z40550506
Keywords : phosphonic acids * pyrimidines * 1,3,5-triazines * microwave-assisted synthesis * influenza virus
Subject RIV: CC - Organic Chemistry
Impact factor: 2.803, year: 2012

Polysubstituted pyrimidinylphosphonic and 1,3,5-triazinylphosphonic acids with potential biological properties were prepared in high yields by the microwave-assisted Michaelis-Arbuzov reaction of trialkyl phosphite with the corresponding halopyrimidines and halo-1,3,5-triazines, respectively, followed by the standard deprotection of the phosphonate group using TMSBr in acetonitrile.
Permanent Link: http://hdl.handle.net/11104/0209784