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Plasma-membrane hyperpolarization diminishes the cation efflux via Nha1 antiporter and Ena ATPase under potassium-limiting conditions
- 1.0377369 - FGÚ 2013 RIV US eng J - Journal Article
Zahrádka, Jaromír - Sychrová, Hana
Plasma-membrane hyperpolarization diminishes the cation efflux via Nha1 antiporter and Ena ATPase under potassium-limiting conditions.
FEMS Yeast Research. Roč. 12, č. 4 (2012), s. 439-446. ISSN 1567-1356. E-ISSN 1567-1364
R&D Projects: GA MŠMT(CZ) LC531; GA AV ČR(CZ) IAA500110801
Grant - others:Univerzita Karlova(CZ) 33779266
Institutional research plan: CEZ:AV0Z50110509
Keywords : potassium uptake * potassium efflux * yeast * plasma-membrane potential
Subject RIV: EE - Microbiology, Virology
Impact factor: 2.462, year: 2012
A series of experiments with strains lacking various combinations of potassium efflux and uptake systems revealed that all three potassium exporting systems, the Nha1 antiporter, Ena ATPase and Tok1 channel contribute to potassium homeostasis and are active upon potassium limitation in wild-type cells. In trk1 delta trk2 delta mutants, the potassium efflux via potassium exporters Nha1 and Ena1 is diminished and can be restored either by the expression of TRK1 or deletion of TOK1. In both cases, the relative hyperpolarization of trk1 delta trk2 delta cells is decreased. Thus it is the plasma-membrane potential which serves as the common mechanism regulating the activity of K+ exporting systems
Permanent Link: http://hdl.handle.net/11104/0209541
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