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Yeast 14-3-3 proteins participate in the regulation of cell cation homeostasis via interaction with Nha1 alkali-metal-cation/proton antiporter

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    0377359 - FGÚ 2013 RIV NL eng J - Journal Article
    Zahrádka, Jaromír - Van Heusden, G.P.H. - Sychrová, Hana
    Yeast 14-3-3 proteins participate in the regulation of cell cation homeostasis via interaction with Nha1 alkali-metal-cation/proton antiporter.
    Biochimica et Biophysica Acta-General Subjects. Roč. 1820, č. 7 (2012), s. 849-858. ISSN 0304-4165. E-ISSN 1872-8006
    R&D Projects: GA MŠMT(CZ) LC531; GA MŠMT(CZ) OC10012; GA AV ČR(CZ) IAA500110801
    Institutional research plan: CEZ:AV0Z50110509
    Institutional support: RVO:67985823
    Keywords : yeast * 14-3-3 proteins * ion homeostasis * Nha1 antiporter
    Subject RIV: CE - Biochemistry
    Impact factor: 3.848, year: 2012

    Disruption of BMH1 in S. cerevisiae, encoding the major 14-3-3 isoform, resulted in an increased sensitivity to Na+, Li+ and K+ and to cationic drugs. BMH1 deletion did not affect plasma membrane potential. Testing the genetic interaction between BMH genes and genes encoding five plasma-membrane potassium and sodium transporters revealed, that 14-3-3 proteins neither interact with the potassium uptake systems, nor with the potassium-specific channel nor with the Na+(K+)-ATPases. Instead, a genetic interaction was identified between BMH1 and NHA1 which encodes an Na+(K+)/H+ antiporter
    Permanent Link: http://hdl.handle.net/11104/0209534

     
     
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