CD36 overexpression predisposes to arrhythmias but reduces infarct size in spontaneously hypertensive rats: gene expression profile analysis

0377338 - FGÚ 2013 RIV US eng J - Journal Article
Neckář, Jan - Šilhavý, Jan - Zídek, Václav - Landa, Vladimír - Mlejnek, Petr - Šimáková, Miroslava - Seidman, J. G. - Seidman, Ch. - Kazdová, L. - Klevstig, M. - Novák, F. - Vecka, M. - Papoušek, František - Houštěk, Josef - Drahota, Zdeněk - Kurtz, T. W. - Kolář, František - Pravenec, Michal
CD36 overexpression predisposes to arrhythmias but reduces infarct size in spontaneously hypertensive rats: gene expression profile analysis.
Physiological Genomics. Roč. 44, č. 2 (2012), s. 173-182. ISSN 1094-8341. E-ISSN 1531-2267
R&D Projects: GA MŠMT(CZ) ME08006; GA MŠMT(CZ) 1M0520; GA MŠMT(CZ) OC08017; GA MŠMT(CZ) 1M0510; GA MZd(CZ) NR9359; GA MZd(CZ) NR9387; GA MZd(CZ) NS9757; GA MZd(CZ) NS10504; GA AV ČR(CZ) IAA500110805; GA AV ČR(CZ) IAAX01110901; GA AV ČR(CZ) KAN200520703; GA ČR(CZ) GD305/08/H037; GA ČR GAP301/10/0756; GA MŠMT 7E10067
Institutional research plan: CEZ:AV0Z50110509
Keywords : Cd36 * spontaneously hypertensive rat * arrhythmias * infarct size * gene expression profiles
Subject RIV: FA - Cardiovascular Diseases incl. Cardiotharic Surgery
Impact factor: 2.806, year: 2012

We analyzed the effects of mutant Cd36 on susceptibility to ischemic ventricular arrhythmias and myocardial infarction in adult SHR-Cd36 transgenic rats with wild type Cd36 compared to age-matched SHR controls. Our results showed that transgenic expression of Cd36 plays an important role in modulating the incidence and severity of ischemic and reperfusion ventricular arrhythmias and myocardial infarct size induced by coronary artery occlusion. The proarrhythmic effect of Cd36 transgene appears to be dependent on adrenergic stimulation
Permanent Link: http://hdl.handle.net/11104/0209517