Chronic endothelin A receptor blockade attenuates contribution of sympathetic nervous system to salt hypertension development in adult but not in young Dahl rats

0376806 - FGÚ 2013 RIV GB eng J - Journal Article
Zicha, Josef - Dobešová, Zdenka - Kuneš, Jaroslav - Vaněčková, Ivana
Chronic endothelin A receptor blockade attenuates contribution of sympathetic nervous system to salt hypertension development in adult but not in young Dahl rats.
Acta Physiologica. Roč. 205, č. 1 (2012), s. 124-132. ISSN 1748-1708. E-ISSN 1748-1716
R&D Projects: GA MŠMT(CZ) 1M0510; GA ČR(CZ) GA305/09/0336; GA AV ČR(CZ) IAA500110902
Institutional research plan: CEZ:AV0Z50110509
Keywords : Endothelin-1 * salt hypertension * Dahl rats
Subject RIV: FA - Cardiovascular Diseases incl. Cardiotharic Surgery
Impact factor: 4.382, year: 2012

The role of endothelin-1 in the development or the maintenance of salt hypertension induced in young (4-week-old) or adult (12-week-old) Dahl rats was compared. Acute ET(A) receptor blockade lowered BP in both age groups of salt hypertensive Dahl rats more than in rats fed a low-salt diet (but without any age-dependent difference). Chronic ET(A) receptor blockade strongly attenuated the development of salt hypertension and cardiac hypertrophy in adult rats, but it had no significant effects on salt hypertension in young animals. Pronounced BP reduction induced in adult salt hypertensive rats by chronic ambrisentan treatment was attributed to attenuated sympathetic BP component, without changes in nitric oxide (NO)-dependent BP regulation. Thus ET(A) receptor-mediated ET-1 effects play an important role in salt hypertension of adult but not young Dahl rats
Permanent Link: http://hdl.handle.net/11104/0209116