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In Vitro Assembly of Virus-Like Particles of a Gammaretrovirus, the Murine Leukemia Virus XMRV
- 1.0376627 - ÚOCHB 2013 RIV US eng J - Journal Article
Hadravová, Romana - de Marco, A. - Ulbrich, P. - Štokrová, Jitka - Doležal, Michal - Pichová, Iva - Ruml, T. - Briggs, J. A. G. - Rumlová, Michaela
In Vitro Assembly of Virus-Like Particles of a Gammaretrovirus, the Murine Leukemia Virus XMRV.
Journal of Virology. Roč. 86, č. 3 (2012), s. 1297-1306. ISSN 0022-538X. E-ISSN 1098-5514
R&D Projects: GA ČR GA204/09/1388; GA MŠMT 1M0508
Grant - others:GA MŠk(CZ) 1M0520
Program: 1M
Institutional research plan: CEZ:AV0Z40550506
Keywords : human-immunodeficiency-virus * Rous sarcoma virus * chronic-fatigue-syndrome * Pfizer monkey virus * N-terminal domain
Subject RIV: CE - Biochemistry
Impact factor: 5.076, year: 2012
We show here that Xenotropic murine leukeamia virus (XMRV) Delta ProCANC or Delta 10CANC proteins assemble into immature-like, spherical particles. Detailed 3D structural analysis of these particles revealed that below a disordered N-terminal capsid protein (CA) layer the C-terminus of CA assembles a typical immature hexameric lattice, which is linked by rod-like densities with the ribonucleocapsid protein.
Permanent Link: http://hdl.handle.net/11104/0208981
Number of the records: 1