Secreted proteins as a fundamental source for biomarker discovery

0376119 - ÚIACH 2013 RIV DE eng J - Journal Article
Šťastná, Miroslava - Van Eyk, J.E.
Secreted proteins as a fundamental source for biomarker discovery.
Proteomics. Roč. 12, 4-5 (2012), s. 722-735. ISSN 1615-9853. E-ISSN 1615-9861
Institutional research plan: CEZ:AV0Z40310501
Keywords : conditioned media * secreted proteins * proteomics * biomarker discovery
Subject RIV: CB - Analytical Chemistry, Separation
Impact factor: 4.132, year: 2012

We discuss the proteins secreted by three progenitor cell types (smooth muscle, endothelial and cardiac progenitor cells) and two adult cell types (neonatal rat ventrical myocytes and smooth muscle cells) which can be relevant to cardiovascular research and which have been recently published in the literature. We found, at least for secretome studies included in this review, that secretomes of progenitor and adult cells overlap by 48% but the secretomes are very distinct among progenitor cell themselves as well as between adult cells. As expected, many proteins have been identified as biomarkers in cancer but 18 proteins (out of 62) have been tested as biomarkers in cardiovascular diseases as well.
Permanent Link: http://hdl.handle.net/11104/0208611