Number of the records: 1
Tick saliva suppresses IFN signalling in dendritic cells upon Borrelia afzelii infection
- 1.0375992 - BC 2013 RIV GB eng J - Journal Article
Lieskovská, Jaroslava - Kopecký, Jan
Tick saliva suppresses IFN signalling in dendritic cells upon Borrelia afzelii infection.
Parasite immunology. Roč. 34, č. 1 (2012), s. 32-39. ISSN 0141-9838. E-ISSN 1365-3024
R&D Projects: GA MŠMT(CZ) LC06009
Institutional support: RVO:60077344
Keywords : Borrelia * dendritic cells * interferon signalling * tick saliva
Subject RIV: EC - Immunology
Impact factor: 2.208, year: 2012
Type I interferons (IFN-a and IFN-beta) are crucial determinants of the host immune response and tick saliva modulates this response, thus facilitating the transmission of tickborne pathogens. The current study therefore examines the effect of Ixodes ricinus tick saliva on IFN-beta signalling in murine dendritic cells using lipopolysaccharide (LPS) and Borrelia afzelii spirochaetes as inducers. Our results show that Borrelia-induced activation of STAT-1 was suppressed by tick saliva. Our data indicate that similar to I. ricinus tick saliva may modulate the host immune response by attenuating the initial signal transduction pathway of type I IFN.
Permanent Link: http://hdl.handle.net/11104/0208513
Number of the records: 1