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Early stage of nucleic acid electrochemistry. Detection of DNA damage in X-ray-irradiated rats
- 1.0375926 - BFÚ 2013 RIV CZ eng J - Journal Article
Paleček, Emil
Early stage of nucleic acid electrochemistry. Detection of DNA damage in X-ray-irradiated rats.
Collection of Czechoslovak Chemical Communications. Roč. 76, č. 12 (2011), s. 1799-1810. ISSN 0010-0765
R&D Projects: GA MŠMT(CZ) ME09038; GA MŠMT(CZ) LC06035
Grant - others:GA ČR(CZ) GAP301/11/2055
Institutional research plan: CEZ:AV0Z50040507; CEZ:AV0Z50040702
Keywords : hydrogen evolution reaction * mediated catalysis * EC mechanism
Subject RIV: BO - Biophysics
Impact factor: 1.283, year: 2011
It is shown that already before 1960 it was possible to detect damage to DNA in X-ray-irradiated rats by means of OP. DNA samples from irradiated animals produced significantly larger OP anodic guanine signal indicating changes in the DNA structure. At present, radiation-induced strand breaks and damage to bases in DNA can be electrochemically detected at high sensitivity.
Permanent Link: http://hdl.handle.net/11104/0208460
Number of the records: 1