Stem Cells and Cancer Stem Cells

0375344 - ÚEM 2013 RIV US eng M - Monography Chapter
Anděrová, Miroslava - Honsa, Pavel
Neural Stem/Progenitor Cell Proliferation and Differentiation: Role of Sonic Hedgehog and Wingless/Int-1 Proteins.
Stem Cells and Cancer Stem Cells. Volume 4. New York: Springer Science+Business Media, 2012 - (Hayat, M.), s. 3-18. ISBN 978-94-007-2827-1
R&D Projects: GA ČR GA305/09/0717
Institutional research plan: CEZ:AV0Z50390703
Keywords : Adult neurogenesis * neural stem cells * CNS disorders
Subject RIV: FH - Neurology

Here we review key findings that demonstrate the role of Sonic hedgehog and Wingless-Int proteins (Wnts) in modulating the proliferation of neural stem/progenitor cells and affecting the fate decision of neural stem/progenitor cells during embryonic development. Moreover, we also review current findings elucidating the role of these morphogens during neonatal and adult neural stem cell differentiation and their possible role in adult neurogenesis induced by neurodegenerative disorders of the CNS.
Permanent Link: http://hdl.handle.net/11104/0208021