Appearance of alarmin HMGB1 in small intestine and plasma of gnotobiotic piglets infected with enteric pathogens

0375210 - MBÚ 2012 RIV CZ eng A - Abstract
Šplíchal, Igor - Šplíchalová, Alla - Chmelařová, Petra - Trebichavský, Ilja
Appearance of alarmin HMGB1 in small intestine and plasma of gnotobiotic piglets infected with enteric pathogens.
Sborník přednášek VI. sympozia Společnosti pro probiotika a prebiotika. Praha: ČZU Praha, 2011. s. 19-19. ISBN 978-80-213-2173-1.
[Sympozium Společnosti pro probiotika a prebiotika /6./. 19.04.2011, Praha]
R&D Projects: GA MŠMT ME 915; GA ČR GA523/07/0572
Institutional research plan: CEZ:AV0Z50200510
Keywords : S. Typhimurium * E. coli
Subject RIV: EC - Immunology

One week old gnotobiotic piglets were orally infected with enteric bacterial pathogens S. Typhimurium or E. coli O55. High levels of HMGB1 in intestine and plasma of infected piglets 24 hours after infection correlated with clinical state of piglets (lethargy, anorexia, diarrhea) and severity of infection. Piglets colonized with probiotic E. coli Nissle 1917 kept the values comparable with germ-free controls
Permanent Link: http://hdl.handle.net/11104/0207933