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Biophysical characterization of recombinant human ameloblastin
- 1.0374865 - MBÚ 2012 RIV DK eng J - Journal Article
Wald, Tomáš - Bednárová, Lucie - Osička, Radim - Pachl, Petr - Šulc, Miroslav - Lyngstadaas, S. P. - Slabý, Ivan - Vondrášek, Jiří
Biophysical characterization of recombinant human ameloblastin.
European Journal of Oral Sciences. Roč. 119, č. 1 (2011), s. 261-269. ISSN 0909-8836. E-ISSN 1600-0722
R&D Projects: GA ČR GAP302/10/0427; GA MŠMT LC512
Institutional research plan: CEZ:AV0Z50200510; CEZ:AV0Z40550506; CEZ:AV0Z50520701
Keywords : circular dichroism spectroscopy * dynamic light scattering * enamel matrix protein
Subject RIV: EE - Microbiology, Virology
Impact factor: 1.878, year: 2011
Ameloblastin (AMBN) is a protein expressed mainly during dental hard tissue development. Biochemically, it is classified as an intrinsically disordered protein (IDP). Its biological role remains largely unknown; however, the question of AMBN function will undoubtedly be connected to its structural properties and its potential for protein-protein and protein-cell interactions. A basic biophysical characterization of human recombinant ameloblastin (hrAMBN) and its N- and C-terminal domains by means of circular dichroism spectroscopy and dynamic light scattering showed that under physiological conditions ameloblastin is an IDP with a prevalent polyproline-II (PPII) conformation
Permanent Link: http://hdl.handle.net/11104/0207680
Number of the records: 1