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Dynamics of the base of ribosomal A-site finger revealed by molecular dynamics simulations and Cryo-EM

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    0373405 - BFÚ 2012 RIV GB eng J - Journal Article
    Réblová, Kamila - Rázga, Filip - Li, W. - Gao, H. - Frank, J. - Šponer, Jiří
    Dynamics of the base of ribosomal A-site finger revealed by molecular dynamics simulations and Cryo-EM.
    Nucleic Acids Research. Roč. 38, č. 4 (2010), s. 1325-1340. ISSN 0305-1048. E-ISSN 1362-4962
    R&D Projects: GA MŠMT(CZ) LC06030
    Keywords : molecular dynamics * Cryo-electron microscopy * RNA
    Subject RIV: BO - Biophysics
    Impact factor: 7.836, year: 2010

    We carried out molecular dynamics simulations of the base of the A-site finger from archaeal and three bacterial large subunits. The study showed that despite noticeable differences in the secondary structures, the studied segments adopt almost identical fold and exhibit similar stochastic fluctuations. Geometries of segments from the simulations correspond to structures obtained by Cryo-electron microscopy.
    Permanent Link: http://hdl.handle.net/11104/0206513

     
     
Number of the records: 1  

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