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Cytotoxicity, cellular uptake, glutathione and DNA interactions of an antitumor large-ring PtII chelate complex incorporating the cis-1,4-diaminocyclohexane carrier ligand
- 1.0373400 - BFÚ 2012 RIV US eng J - Journal Article
Kašpárková, Jana - Suchánková, T. - Halámiková, Anna - Zerzánková, Lenka - Vrána, Oldřich - Margiotta, N. - Natile, G. - Brabec, Viktor
Cytotoxicity, cellular uptake, glutathione and DNA interactions of an antitumor large-ring PtII chelate complex incorporating the cis-1,4-diaminocyclohexane carrier ligand.
Biochemical Pharmacology. Roč. 79, č. 4 (2010), s. 552-564. ISSN 0006-2952. E-ISSN 1873-2968
R&D Projects: GA MŠMT(CZ) LC06030; GA AV ČR(CZ) KAN200200651
Keywords : DNA * platinum * cancer
Subject RIV: BO - Biophysics
Impact factor: 4.889, year: 2010
This work describes a mechanistic study aimed at finding differences in those features of mechansim of activity of new antitumor PtII complex [PtCl2(cis-1,4-DACH)] (DACH = diaminocyclohexane) which are associated with its different biological effects in comparison with conventional cisplatin.
Permanent Link: http://hdl.handle.net/11104/0206508
Number of the records: 1