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Mechanistic insights into antitumor effects of new dinuclear cis PtII complexes containing aromatic linkers
- 1.0373395 - BFÚ 2012 RIV US eng J - Journal Article
Zerzánková, Lenka - Kostrhunová, Hana - Vojtíšková, Marie - Nováková, Olga - Suchánková, T. - Lin, M. - Guo, Z. - Kašpárková, Jana - Brabec, Viktor
Mechanistic insights into antitumor effects of new dinuclear cis PtII complexes containing aromatic linkers.
Biochemical Pharmacology. Roč. 80, č. 3 (2010), s. 344-351. ISSN 0006-2952. E-ISSN 1873-2968
R&D Projects: GA MŠMT(CZ) LC06030; GA AV ČR(CZ) KAN200200651
Keywords : DNA * platinum * cancer
Subject RIV: BO - Biophysics
Impact factor: 4.889, year: 2010
The primary objective was to understand more deeply the molecular mechanism underlying different antitumor effects of dinuclear Pt-II complexes containing aromatic linkers of different length, ([cisPt( NH3)(2)Cl](2)(4,4'-methylenedianiline)}(2+) (1) and {[cis-Pt(NH3)(2)Cl](2)(alpha,alpha'-diamino-p-xylene)}(2+) (2). These complexes belong to a new generation of promising polynuclear platinum drugs resistant to decomposition by sulfur nucleophiles which hampers clinical use of bifunctional polynuclear trans Pt-II complexes hitherto tested.
Permanent Link: http://hdl.handle.net/11104/0206504
Number of the records: 1