Ribonucleases, nucleases and antiangiogenins in antiproliferative activities

0373351 - ÚŽFG 2012 RIV AE eng J - Journal Article
Matoušek, Josef
Ribonucleases, nucleases and antiangiogenins in antiproliferative activities.
Current Signal Transduction Therapy. Roč. 6, č. 3 (2011), s. 363-382. ISSN 1574-3624
R&D Projects: GA ČR GA521/06/1149; GA ČR GA521/09/1214
Institutional research plan: CEZ:AV0Z50450515
Keywords : Angiogenin * Anticancer * Antiproliferative
Subject RIV: CE - Biochemistry
Impact factor: 0.500, year: 2011

The animal ribonucleases and plant nucleases are selective cytotoxic enzymes with several biological activities inclusively also with antitumorous effects. The first attention from animal researches is dated to 1938 year, meanwhile plant enzyme investigators awoke their attention in last time. The bovine pancreatic ribonuclease, after the first structurally studies, allured very soon the peoples with functionally interests. The results of studies directed to antitumor effect were firstly very weak. The latter isolated bovine seminal ribonuclease was more effective from this aspect. Also human pancreatic ribonuclease stimulated interest about its antitumor activity what was realized by its dimerization and other molecular studies. Ribonuclease inhibitors have been very limited substances in the cytotoxicity of antitumor effectivity. On the other side a conjugation of cytostatic enzymes with polymers enhanced the antitumor activity of them and lowered their toxicity.
Permanent Link: http://hdl.handle.net/11104/0206464