Formation of 1,2; 3,4-diepoxybutane specific hemoglobin adducts in 1,3-butadiene exposed workers

0372929 - ÚEM 2013 RIV US eng J - Journal Article
Boysen, G. - Georgieva, N. I. - Bordeerat, N. K. - Šrám, Radim - Vacek, P. - Albertini, R. J. - Swenberg, J. A.
Formation of 1,2; 3,4-diepoxybutane specific hemoglobin adducts in 1,3-butadiene exposed workers.
Toxicological Sciences. Roč. 125, č. 1 (2012), s. 30-40. ISSN 1096-6080. E-ISSN 1096-0929
Institutional research plan: CEZ:AV0Z50390703
Keywords : 1,3-butadiene exposure * carcinogenicity * occupational exposure
Subject RIV: DN - Health Impact of the Environment Quality
Impact factor: 4.328, year: 2012

1,3-butadiene (BD) carcinogenicity has been attributed to its metabolism to several reactive epoxide metabolites and formation of the highly mutagenic 1,2:3,4-diepoxybutane (DEB) has been hypothesized to drive mutagenesis and carcinogenesis at exposures experienced in humans. This work reports the formation of DEB-specific pyr-Val in BD-exposed workers as a biomarker of DEB formation. The results suggest that formation of DEB relative to other epoxides is significantly different in the highest exposed polymer workers compared to controls and BD monomer workers.
Permanent Link: http://hdl.handle.net/11104/0206130