Cyanobacterial cytotoxicity versus toxicity to brine shrimp Artemia salina

0372518 - MBÚ 2012 RIV GB eng J - Journal Article
Hisem, D. - Hrouzek, Pavel - Tomek, P. - Tomšíčková, J. - Zapomělová, Eliška - Skácelová, K. - Lukešová, Alena - Kopecký, Jiří
Cyanobacterial cytotoxicity versus toxicity to brine shrimp Artemia salina.
Toxicon. Roč. 57, č. 1 (2011), s. 76-83. ISSN 0041-0101. E-ISSN 1879-3150
R&D Projects: GA ČR GAP504/10/1501
Institutional research plan: CEZ:AV0Z50200510; CEZ:AV0Z60170517; CEZ:AV0Z60660521
Keywords : Secondary metabolites * Brine shrimp bioassay * Health risk assessment
Subject RIV: EE - Microbiology, Virology
Impact factor: 2.508, year: 2011

Heterocytous cyanobacteria from various habitats were screened for toxicity to brine shrimp Artemia salina and the murine lymphoblastic cell line Sp/2 in order to compare these two testing models for evaluation of risk posed by cyanobacteria to human health. Methanol extracts of biomass and cultivation media were tested for toxicity and selected extracts were fractionated to determine the active fraction. We found a significant toxic effect to A. sauna and to Sp/2 cells in 5.2% and 31% of studied extracts, respectively. Only 8.6% of the tested strains were highly toxic to both A. sauna and the Sp/2 cell line, and only two of the tested strains were toxic to A. sauna and not to the murine cell line
Permanent Link: http://hdl.handle.net/11104/0205819