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Cation binding to 15-TBA quadruplex DNA is a multiple-pathway cation-dependent process
- 1.0372033 - BFÚ 2012 RIV GB eng J - Journal Article
Reshetnikov, R.V. - Šponer, Jiří - Rassokhina, O.I. - Kopylov, A.M. - Tsvetkov, P.O. - Makarov, A.A. - Golovin, A.V.
Cation binding to 15-TBA quadruplex DNA is a multiple-pathway cation-dependent process.
Nucleic Acids Research. Roč. 39, č. 22 (2011), s. 9789-9802. ISSN 0305-1048. E-ISSN 1362-4962
R&D Projects: GA AV ČR(CZ) IAA400040802; GA ČR(CZ) GA203/09/1476; GA ČR(CZ) GAP208/11/1822; GA MŠMT(CZ) LC06030
Institutional research plan: CEZ:AV0Z50040507; CEZ:AV0Z50040702
Keywords : QM/MM * quadruplex DNA * molecular dynamics simulation
Subject RIV: BO - Biophysics
Impact factor: 8.026, year: 2011
A combination of explicit solvent molecular dynamics simulation, hybrid quantum mechanics/molecular mechanics approach and isothermal tetration calorimetry was used to investigate the atomistic picture of ion binding to 15-mer thrombin-binding quadruplex DNA (G-DNA) aptamer. Binding of ions to G-DNA is complex multiple pathway process, which is strongly affected by the type of the cation.
Permanent Link: http://hdl.handle.net/11104/0205428
Number of the records: 1