Morphogenesis and bone integration of the mouse mandibular third molar

0371610 - ÚŽFG 2012 RIV US eng J - Journal Article
Chlastáková, Ivana - Lungová, V. - Wells, K. - Tucker, A. S. - Radlanski, R.J. - Míšek, Ivan - Matalová, Eva
Morphogenesis and bone integration of the mouse mandibular third molar.
European Journal of Oral Sciences. Roč. 119, č. 4 (2011), s. 265-274. ISSN 0909-8836. E-ISSN 1600-0722
R&D Projects: GA AV ČR IAA600450904; GA ČR GC524/08/J032
Institutional research plan: CEZ:AV0Z50450515
Keywords : 3D models * apoptosis * osteoclast activity
Subject RIV: ED - Physiology
Impact factor: 1.878, year: 2011

The mouse third molar (M3) develops postnatally and is thus a unique model for studying the integration of a non-mineralized tooth with mineralized bone. This study assessed the morphogenesis of the mouse M3, related to the alveolar bone, comparing M3 development with that of the first molar (M1), the most common model in odontogenesis. The mandibular M3 was evaluated from initiation to eruption by morphology and by assessing patterns of proliferation, apoptosis, osteoclast distribution, and gene expression. Three-dimensional reconstruction and explant cultures were also used. Initiation of M3 occurred perinatally, as an extension of the second molar (M2) which grew into a region of soft mesenchymal tissue above the M2, still far away from the alveolar bone.
Permanent Link: http://hdl.handle.net/11104/0205086