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Whole-cell oxidation of omeprazole sulfide to enantiopure esomeprazole with Lysinibacillus sp B71
- 1.0371609 - MBÚ 2012 RIV NL eng J - Journal Article
Babiak, Petr - Kyslíková, Eva - Štěpánek, Václav - Valešová, Renata - Palyzová, Andrea - Marešová, Helena - Hájíček, J. - Kyslík, Pavel
Whole-cell oxidation of omeprazole sulfide to enantiopure esomeprazole with Lysinibacillus sp B71.
Bioresource Technology. Roč. 102, č. 17 (2011), s. 7621-7626. ISSN 0960-8524. E-ISSN 1873-2976
R&D Projects: GA MŠMT 2B08064
Institutional research plan: CEZ:AV0Z50200510
Keywords : Biotransformation * Asymmetric oxidation * Esomeprazole
Subject RIV: EE - Microbiology, Virology
Impact factor: 4.980, year: 2011
A Gram-positive bacterium oxidizing omeprazole sulfide to (S)-sulfoxide esomeprazole was isolated from soil polluted with elemental sulfur. The strain exhibited the highest identity with the genus Lysinibacillus and catalyzed oxidation of omeprazole sulfide into enantiopure esomeprazole with conversion of 77% in a stirred bioreactor, fed-batch culture. No consecutive oxidation of (S)-sulfoxide to sulfone was observed during whole-cell catalysis. The unique characteristics of the catalyst provide a solid basis for further improvement and development of sustainable green bioprocess
Permanent Link: http://hdl.handle.net/11104/0205085
Number of the records: 1