Perinatal programming of body weight control by leptin: putative roles of AMP kinase and muscle thermogenesis

0371070 - FGÚ 2012 RIV US eng J - Journal Article
Pico, C. - Macek Jílková, Zuzana - Kůs, Vladimír - Palou, A. - Kopecký, Jan
Perinatal programming of body weight control by leptin: putative roles of AMP kinase and muscle thermogenesis.
American Journal of Clinical Nutrition. Roč. 94, 6 suppl. (2011), 1830S-1837S. ISSN 0002-9165. E-ISSN 1938-3207.
[International Conference on The Power of Programming - Developmental Origins of Health and Disease. Munich, 06.05.2010-08.05.2010]
Institutional research plan: CEZ:AV0Z50110509
Keywords : leptin * perinatal programming * AMPK * muscle thermogenesis
Subject RIV: FB - Endocrinology, Diabetology, Metabolism, Nutrition
Impact factor: 6.669, year: 2011

Leptin represents a candidate for the programming of the lean phenotype as suggested by 1) the presence of leptin in breast milk and its absence in infant formula, 2) a human study that showed a negative correlation between leptin concentrations in breast milk and body weights of infants until 2 y of age, and 3) intervention studies in animals. High leptin sensitivity, which is associated with leanness, and leptin resistance in obesity may be programmed by the early life environment. Available data have suggested the involvement of nonshivering thermogenesis induced by a leptin–AMP-activated protein kinase axis in oxidative muscles, which is based on lipid metabolism
Permanent Link: http://hdl.handle.net/11104/0204700