Number of the records: 1
Myeloperoxidase attracts neutrophils by physical forces
- 1.0370692 - BFÚ 2012 RIV US eng J - Journal Article
Klinke, A. - Nussbaum, C. - Kubala, Lukáš - Friedrichs, K. - Rudolph, T.K. - Rudolph, V. - Paust, H.-J. - Schröder, Ch. - Benten, D. - Lau, D. - Szocs, K. - Furtmüller, P.G. - Heeringa, P. - Sydow, K. - Duchstein, H.-J. - Ehmke, H. - Schumacher, U. - Meinertz, T. - Sperandio, M. - Baldus, S.
Myeloperoxidase attracts neutrophils by physical forces.
Blood. Roč. 117, č. 4 (2011), s. 1350-1358. ISSN 0006-4971. E-ISSN 1528-0020
Institutional research plan: CEZ:AV0Z50040507; CEZ:AV0Z50040702
Keywords : myeloperoxidase * polymorphonuclear neutrophils * glycocalyx
Subject RIV: BO - Biophysics
Impact factor: 9.898, year: 2011
Study describes a novel mechanism underlying neutrophil motility and highlight a so-far unrecognized role for MPO in the recruitment of PMN, which is independent of the enzyme's catalytic activity. Instead, PMN attraction is communicated by MPO's positive charge, an observation that calls for revisiting the role of MPO in innate immunity and the impact of physical forces on the recruitment of neutrophils.
Permanent Link: http://hdl.handle.net/11104/0204415
Number of the records: 1