N-Acetyl-D-glucosamine-coated polyamidoamine dendrimer promotes tumor-specific B cell responses via natural killer cell activation

0370656 - MBÚ 2012 RIV NL eng J - Journal Article
Huliková, Katarína - Svoboda, Jan - Benson, Veronika - Grobárová, Valeria - Fišerová, Anna
N-Acetyl-D-glucosamine-coated polyamidoamine dendrimer promotes tumor-specific B cell responses via natural killer cell activation.
International Immunopharmacology. Roč. 11, č. 8 (2011), s. 955-961. ISSN 1567-5769. E-ISSN 1878-1705
R&D Projects: GA ČR GA303/09/0477; GA ČR GD310/08/H077; GA AV ČR IAA601680801; GA AV ČR IAA500200620
Institutional research plan: CEZ:AV0Z50200510
Keywords : GN8P * B16F10 melanoma * Antibody formation
Subject RIV: EC - Immunology
Impact factor: 2.376, year: 2011

N-Acetyl-D-glucosamine-coated polyamidoamine dendrimer (GN8P), exerting high binding affinity to rodent recombinant NKR-P1A and NKR-P1C activating proteins, was shown previously to delay the development of rat colorectal carcinoma as well as mouse B16F10 melanoma, and to potentiate antigen-specific antibody formation in healthy C57BL/6 mice via NK cell stimulation. In this study, we investigated whether GN8P also modulates tumor-specific B cell responses. Serum anti-B16F10 melanoma IgG levels, IgG2a mRNA expression, antibody dependent cell-mediated cytotoxicity (ADCC), and counts of plasma as well as antigen presenting B cells were evaluated in tumor-bearing C57BL/6 mice treated with GN8P and in respective controls
Permanent Link: http://hdl.handle.net/11104/0204386