Activity of antimicrobial peptides from the venom of hymenoptera against Candida albicans biofilms

0370598 - ÚOCHB 2012 CZ eng C - Conference Paper (international conference)
Putnová, Helena - Fučík, Vladimír - Monincová, Lenka - Čeřovský, Václav - Slaninová, Jiřina
Activity of antimicrobial peptides from the venom of hymenoptera against Candida albicans biofilms.
Biologically Active Peptides. 12th Conference. Praha: Institute of Organic Chemistry and Biochemistry AS CR, v. v. i, 2011 - (Slaninová, J.), s. 107-110. Collection Symposium Series, 13. ISBN 978-80-86241-44-9.
[Biologically Active Peptides /12./. Praha (CZ), 27.04.2011-29.04.2011]
R&D Projects: GA ČR GA203/08/0536
Institutional research plan: CEZ:AV0Z40550506
Keywords : biofilm * antifungal activity * antimicrobial peptides * XTT assay
Subject RIV: CC - Organic Chemistry

Biofilms are nowadays a serious problem especially with immunosuppressed patients. These highly resistant agglomerations are formed by cells which are firmly adhered to the surface. In this work, the effect of antimicrobial peptides isolated from venom reservoirs of wild bees were tested against Candida albicans biofilms. The results show that some synthetic analogues exhibit potency to kill quickly the yeast biofilm cells. On the contrary, some analogues active against planktonic cells are only little active or inactive against biofilms.
Permanent Link: http://hdl.handle.net/11104/0204348