In vitro and in vivo antimicrobial effect of lasioglossins on the Candida albicans

0370586 - ÚOCHB 2012 CZ eng C - Conference Paper (international conference)
Kašperová, A. - Turánek, J. - Čeřovský, Václav - Raška, M.
In vitro and in vivo antimicrobial effect of lasioglossins on the Candida albicans.
Biologically Active Peptides. 12th Conference. Praha: Institute of Organic Chemistry and Biochemistry AS CR, v. v. i, 2011 - (Slaninová, J.), s. 54-57. Collection Symposium Series, 13. ISBN 978-80-86241-44-9.
[Biologically Active Peptides /12./. Praha (CZ), 27.04.2011-29.04.2011]
R&D Projects: GA ČR GA203/08/0536
Institutional research plan: CEZ:AV0Z40550506
Keywords : Candida viability * flow cytometry analysis * antimicrobial activity * vaginal candidiasis
Subject RIV: CC - Organic Chemistry

Lasioglossins represent a new group of amphipathic α-helical peptides with significant antimicrobial effect on the Candida albicans. This study examines the antifungal activity of two peptides LL-III and all D-LL-III as measured by the suppression of Candida proliferation and suppression of induced morphological differentiation both in in vitro and in vivo assays. In the in vitro Candida proliferation assay, the inhibitory effect of lasioglossins LL-III and all D-LL-III was more than 70% within 24 h and more than 84% after 48 h of incubation (final concentration of either peptide was 17.5 .mu.M). Delaying of blastoconidial transition to hyphae in vitro and tendency to suppress vaginal candidiasis in experimental mice were detected.
Permanent Link: http://hdl.handle.net/11104/0204338