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Fmoc deprotection by tert-butylamine and its comparison in solution and solid phase synthesis
- 1.0370529 - ÚOCHB 2012 CZ eng C - Conference Paper (international conference)
Flegel, Martin - Flegelová, Z. - Maloň, Petr - Klenerová, V. - Hynie, S.
Fmoc deprotection by tert-butylamine and its comparison in solution and solid phase synthesis.
Biologically Active Peptides. 12th Conference. Praha: Institute of Organic Chemistry and Biochemistry AS CR, v. v. i, 2011 - (Slaninová, J.), s. 41-44. Collection Symposium Series, 13. ISBN 978-80-86241-44-9.
[Biologically Active Peptides /12./. Praha (CZ), 27.04.2011-29.04.2011]
R&D Projects: GA AV ČR(CZ) KAN200520703; GA AV ČR KAN200100801
Institutional research plan: CEZ:AV0Z40550506
Keywords : tert-Butylamine (TBA) * Fmoc deprotection * oxytocin cycle * CD spectra
Subject RIV: CC - Organic Chemistry
tert-Butylamine was employed as the alternative to piperidine for Fmoc deprotection in liquid and solid phase peptide synthesis. Basic kinetic parameters of deprotecting reaction were checked in chosen Fmoc amino acid derivatives. Solid phase synthesis of cyclic part of oxytocin (tocinamide) was worked out and used for CD spectra measurement.
Permanent Link: http://hdl.handle.net/11104/0204314
Number of the records: 1