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High expression of cytoskeletal protein drebrin in TEL/AML1(pos) B-cell precursor acute lymphoblastic leukemia identified by a novel monoclonal antibody
- 1.0370451 - ÚMG 2012 RIV GB eng J - Journal Article
Vašková, M. - Kováč, M. - Volná, P. - Angelisová, Pavla - Mejstříková, E. - Zuna, J. - Brdička, Tomáš - Hrušák, O.
High expression of cytoskeletal protein drebrin in TEL/AML1(pos) B-cell precursor acute lymphoblastic leukemia identified by a novel monoclonal antibody.
Leukemia Research. Roč. 35, č. 8 (2011), s. 1111-1113. ISSN 0145-2126. E-ISSN 1873-5835
R&D Projects: GA MŠMT 2B06064
Institutional research plan: CEZ:AV0Z50520514
Keywords : drebrin * gene expression profiling * immunophenotyping
Subject RIV: EB - Genetics ; Molecular Biology
Impact factor: 2.923, year: 2011
The expression of drebrin, a cytoskeletal protein newly estimated by expression profiling to correlate with the genotype and prognosis of B-cell precursor acute lymphoblastic leukemia (BCP-ALL), was examined by independent methods. After demonstrating its higher expression in TEL/AML1(pos) BCP-ALL by quantitative reverse transcriptase polymerase chain reaction, we developed an anti-drebrin monoclonal antibody (mAb). In a cohort of 86 children with BCP-ALL, we found increased expression of drebrin in TEL/AML1(pos) ALL. In conclusion, relationship of drebrin expression and prognosis or genotype can now be assessed using flow cytometry.
Permanent Link: http://hdl.handle.net/11104/0204252
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