The Wild Bee Venom – Rich Source of Antimicrobial Peptides

0367117 - ÚOCHB 2012 US eng C - Conference Paper (international conference)
Monincová, Lenka - Čujová, Sabína - Slaninová, Jiřina - Fučík, Vladimír - Borovičková, Lenka - Voburka, Zdeněk - Hovorka, Oldřich - Cvačka, Josef - Bednárová, Lucie - Čeřovský, Václav
The Wild Bee Venom – Rich Source of Antimicrobial Peptides.
Peptides: Building Bridges. Proceedings of the Twenty-Second American Peptide Symposium. San Diego: American Peptide Society, 2011 - (Lebl, M.), s. 208-209. ISBN 978-0-9839741-0-9.
[Peptides: Building Bridges. American Peptide Symposium /22./. San Diego (US), 25.06.2011-30.06.2011]
R&D Projects: GA ČR GA203/08/0536
Institutional research plan: CEZ:AV0Z40550506
Keywords : antimicrobial peptide * bee venom * alpha-helical structures
Subject RIV: CC - Organic Chemistry

In our laboratory we have discovered 18 novel antimicrobial peptides isolated from 9 species of wild bee. Fifteen of them belong to the category of linear peptides, which form amphipathic alpha-helical conformations in the presence of membrane-mimicking environment such SDS or organic solvents like trifluoroethanol. One subgroup represents peptides having Pro at position 11 that causes a kink in peptide helical structure. AMPs of the second subgroup do not contain Pro in their sequence. We have also identified unique 25 to 27 residues long AMP containing two intramolecular disulfide bridges. We prepared analogs with improve biological properties.
Permanent Link: http://hdl.handle.net/11104/0201893