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Fluorescence spectroscopy studies of HEK293 cells expressing DOR-Gi1alfa fusion protein; the effect of cholesterol depletion
- 1.0365285 - FGÚ 2012 RIV NL eng J - Journal Article
Brejchová, Jana - Sýkora, Jan - Dlouhá, Kateřina - Roubalová, Lenka - Ostašov, Pavel - Vošahlíková, Miroslava - Hof, Martin - Svoboda, Petr
Fluorescence spectroscopy studies of HEK293 cells expressing DOR-Gi1alfa fusion protein; the effect of cholesterol depletion.
Biochimica Et Biophysica Acta-Biomembranes. Roč. 1808, č. 12 (2011), s. 2819-2829. ISSN 0005-2736. E-ISSN 1879-2642
R&D Projects: GA MŠMT(CZ) LC06063; GA MŠMT(CZ) LC554; GA ČR(CZ) GD305/08/H037
Grant - others:GA ČR(CZ) GAP208/10/1090
Institutional research plan: CEZ:AV0Z50110509; CEZ:AV0Z40400503
Keywords : plasma membrane * cholesterol depletion * fluorescence spectroscopy * hydrophobic membrane interior * delta-opioid receptor (DOR), * G protein
Subject RIV: BO - Biophysics
Impact factor: 3.990, year: 2011
Effect of cholesterol on the organization of plasma membranes and G-protein activation. Cholesterol depletion increases membrane fluidity and mobility of plasma membranes. Cholesterol depletion does not alter the agonist binding site of delta-opioid receptor (DOR), but decreases the ability of DOR agonist to activate G proteins
Permanent Link: http://hdl.handle.net/11104/0200565
Number of the records: 1