Synthesis of PME derivatives on nucleobases with conformation locked via pyrrolidine ring

0361527 - ÚOCHB 2012 CZ eng C - Conference Paper (international conference)
Rejman, Dominik - Pohl, Radek
Synthesis of PME derivatives on nucleobases with conformation locked via pyrrolidine ring.
Chemistry of Nucleic Acid Components. 15th Symposium. Praha: Institute of Organic Chemistry and Biochemistry AS CR, v. v. i., 2011 - (Hocek, M.), s. 446-447. Collection Symposium Series, 12. ISBN 978-80-86241-37-1.
[Chemistry of Nucleic Acid Components /15./. Český Krumlov (CZ), 05.06.2011-10.06.2011]
Institutional research plan: CEZ:AV0Z40550506
Keywords : PME derivatives * locked conformation * nucleoside phosphonic acids * conformationally locked nucleotides * pyrrolidine ring
Subject RIV: CC - Organic Chemistry

Among diverse nucleoside phosphonic acids, the acyclic phosphonate derivatives have been earlier shown to involve some exceptionally potent antiviral drugs (e.g., Cidofovir, Adefovir, and Tenofovir). This work presents the synthesis of such acyclic phosphonate nucleotides conformationally locked via pyrrolidine ring.
Permanent Link: http://hdl.handle.net/11104/0198824